A scintigraphic study of LDL-cholesterol irreversible trapping in a plasma fractionation membrane
Identifieur interne : 017677 ( Main/Repository ); précédent : 017676; suivant : 017678A scintigraphic study of LDL-cholesterol irreversible trapping in a plasma fractionation membrane
Auteurs : RBID : Pascal:98-0463451Descripteurs français
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Abstract
For patients suffering from familial hypercholesterolemia, LDL-cholesterol removal may be achieved by cascade filtration in an extracorporeal process. LDL irreversible trapping into the secondary membrane, due to mechanical or physicochemical capture, is known to be one of the main phenomena responsible for membrane fouling. This study especially focuses on the quantification and the location of LDL irreversibly trapped along the membrane by adsorption and other phenomena. The influence of filtration flux and membrane structure are studied. After an extensive washing following the plasma fractionation procedure, a gamma camera registered the111 In-labeled LDL marker tightly retained on the membrane. The same technique employing labeled magroaggregates of albumin permitted the determination of local filtration fluxes and then the calculation of local wall shear rates. LDL irreversible trapping is responsible for about 10% of the retention of LDL into the membrane. It appears to increase with increasing filtrate flow rate at constant inlet plasma flow rate. This phenomenon is enhanced near the filter outlet where the wall shear rate is minimum. No pore narrowing was observed using mercury porosimetry. The analysis of data together with membrane structure and local fluxes (tangential and transversal) leads us to postulate that a significant part of irreversible fouling occurs at the membrane surface and that the remaining internal irreversible fouling takes place in the membrane macroporous layer.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A scintigraphic study of LDL-cholesterol irreversible trapping in a plasma fractionation membrane</title><author><name sortKey="Legallais, C" uniqKey="Legallais C">C. Legallais</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Technologie de Compiègne, UMR CNRS 6600, BP20529</s1><s2>60205 Compiègne</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Picardie</region><settlement type="city">Compiègne</settlement></placeName></affiliation></author><author><name sortKey="Dore, E" uniqKey="Dore E">E. Dore</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Technologie de Compiègne, UMR CNRS 6600, BP20529</s1><s2>60205 Compiègne</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Picardie</region><settlement type="city">Compiègne</settlement></placeName></affiliation></author><author><name sortKey="Ploux, L" uniqKey="Ploux L">L. Ploux</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Technologie de Compiègne, UMR CNRS 6600, BP20529</s1><s2>60205 Compiègne</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Picardie</region><settlement type="city">Compiègne</settlement></placeName></affiliation></author><author><name sortKey="Fauchet, M" uniqKey="Fauchet M">M. Fauchet</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre d'Imagerie Médicale Avancée, 13 rue Fonds Pernant</s1><s2>60200 Compiègne</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Picardie</region><settlement type="city">Compiègne</settlement></placeName></affiliation></author><author><name sortKey="Jaffrin, M Y" uniqKey="Jaffrin M">M. Y. Jaffrin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Technologie de Compiègne, UMR CNRS 6600, BP20529</s1><s2>60205 Compiègne</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Picardie</region><settlement type="city">Compiègne</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="inist">98-0463451</idno><date when="1998">1998</date><idno type="stanalyst">PASCAL 98-0463451 INIST</idno><idno type="RBID">Pascal:98-0463451</idno><idno type="wicri:Area/Main/Corpus">016340</idno><idno type="wicri:Area/Main/Repository">017677</idno></publicationStmt><seriesStmt><idno type="ISSN">0009-2509</idno><title level="j" type="abbreviated">Chem. eng. sci.</title><title level="j" type="main">Chemical engineering science</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cholesterol LDL</term><term>Extrarenal dialysis</term><term>Filtration</term><term>Fouling</term><term>Hypercholesterolemia</term><term>Indium</term><term>Instrumentation therapy</term><term>Lipids</term><term>Mechanism</term><term>Quantitative analysis</term><term>Scintigraphy</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hypercholestérolémie</term><term>Traitement</term><term>Epuration extrarénale</term><term>Cholestérol LDL</term><term>Filtration</term><term>Analyse quantitative</term><term>Scintigraphie</term><term>Indium</term><term>Encrassement</term><term>Mécanisme</term><term>Traitement instrumental</term><term>Lipide</term><term>Indium 111</term></keywords><keywords scheme="Wicri" type="concept" xml:lang="fr"><term>Analyse quantitative</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For patients suffering from familial hypercholesterolemia, LDL-cholesterol removal may be achieved by cascade filtration in an extracorporeal process. LDL irreversible trapping into the secondary membrane, due to mechanical or physicochemical capture, is known to be one of the main phenomena responsible for membrane fouling. This study especially focuses on the quantification and the location of LDL irreversibly trapped along the membrane by adsorption and other phenomena. The influence of filtration flux and membrane structure are studied. After an extensive washing following the plasma fractionation procedure, a gamma camera registered the<sup>111</sup> In-labeled LDL marker tightly retained on the membrane. The same technique employing labeled magroaggregates of albumin permitted the determination of local filtration fluxes and then the calculation of local wall shear rates. LDL irreversible trapping is responsible for about 10% of the retention of LDL into the membrane. It appears to increase with increasing filtrate flow rate at constant inlet plasma flow rate. This phenomenon is enhanced near the filter outlet where the wall shear rate is minimum. No pore narrowing was observed using mercury porosimetry. The analysis of data together with membrane structure and local fluxes (tangential and transversal) leads us to postulate that a significant part of irreversible fouling occurs at the membrane surface and that the remaining internal irreversible fouling takes place in the membrane macroporous layer.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0009-2509</s0></fA01><fA02 i1="01"><s0>CESCAC</s0></fA02><fA03 i2="1"><s0>Chem. eng. sci.</s0></fA03><fA05><s2>53</s2></fA05><fA06><s2>14</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A scintigraphic study of LDL-cholesterol irreversible trapping in a plasma fractionation membrane</s1></fA08><fA11 i1="01" i2="1"><s1>LEGALLAIS (C.)</s1></fA11><fA11 i1="02" i2="1"><s1>DORE (E.)</s1></fA11><fA11 i1="03" i2="1"><s1>PLOUX (L.)</s1></fA11><fA11 i1="04" i2="1"><s1>FAUCHET (M.)</s1></fA11><fA11 i1="05" i2="1"><s1>JAFFRIN (M. Y.)</s1></fA11><fA14 i1="01"><s1>Université de Technologie de Compiègne, UMR CNRS 6600, BP20529</s1><s2>60205 Compiègne</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Centre d'Imagerie Médicale Avancée, 13 rue Fonds Pernant</s1><s2>60200 Compiègne</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA20><s2>2623-2640 [16 p.]</s2></fA20><fA21><s1>1998</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>7538</s2><s5>354000070007310100</s5></fA43><fA44><s0>0000</s0><s1>© 1998 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>25 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>98-0463451</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Chemical engineering science</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>For patients suffering from familial hypercholesterolemia, LDL-cholesterol removal may be achieved by cascade filtration in an extracorporeal process. LDL irreversible trapping into the secondary membrane, due to mechanical or physicochemical capture, is known to be one of the main phenomena responsible for membrane fouling. This study especially focuses on the quantification and the location of LDL irreversibly trapped along the membrane by adsorption and other phenomena. The influence of filtration flux and membrane structure are studied. After an extensive washing following the plasma fractionation procedure, a gamma camera registered the<sup>111</sup> In-labeled LDL marker tightly retained on the membrane. The same technique employing labeled magroaggregates of albumin permitted the determination of local filtration fluxes and then the calculation of local wall shear rates. LDL irreversible trapping is responsible for about 10% of the retention of LDL into the membrane. It appears to increase with increasing filtrate flow rate at constant inlet plasma flow rate. This phenomenon is enhanced near the filter outlet where the wall shear rate is minimum. No pore narrowing was observed using mercury porosimetry. The analysis of data together with membrane structure and local fluxes (tangential and transversal) leads us to postulate that a significant part of irreversible fouling occurs at the membrane surface and that the remaining internal irreversible fouling takes place in the membrane macroporous layer.</s0></fC01><fC02 i1="01" i2="X"><s0>002B26M</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Hypercholestérolémie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Hypercholesterolemia</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Hipercolesterolemia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Traitement</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Treatment</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="GER"><s0>Aufbereiten</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tratamiento</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Epuration extrarénale</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Extrarenal dialysis</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Depuración extrarrenal</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Cholestérol LDL</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Cholesterol LDL</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Colesterol LDL</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Filtration</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Filtration</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="GER"><s0>Filtration</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Filtración</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Analyse quantitative</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Quantitative analysis</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="GER"><s0>Quantitative Analyse</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Análisis cuantitativo</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Scintigraphie</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Scintigraphy</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Centelleografía</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Indium</s0><s2>NC</s2><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Indium</s0><s2>NC</s2><s5>08</s5></fC03><fC03 i1="08" i2="X" l="GER"><s0>Indium</s0><s2>NC</s2><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Indio</s0><s2>NC</s2><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Encrassement</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Fouling</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Enmugrecimiento</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Mécanisme</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Mechanism</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Mecanismo</s0><s5>10</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Traitement instrumental</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Instrumentation therapy</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Tratamiento instrumental</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Lipide</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Lipids</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Lípido</s0><s5>25</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Indium 111</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Métabolisme pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Metabolic diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Metabolismo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Dyslipémie</s0><s2>NM</s2><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Dyslipemia</s0><s2>NM</s2><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Dislipemia</s0><s2>NM</s2><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Hyperlipoprotéinémie</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Hyperlipoproteinemia</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Hiperlipoproteinemia</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Génie biomédical</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Biomedical engineering</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Ingeniería biomédica</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Exploration radioisotopique</s0><s5>53</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Radionuclide study</s0><s5>53</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Exploración radioisotópica</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Imagerie médicale</s0><s5>54</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Medical imagery</s0><s5>54</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Imageneria medical</s0><s5>54</s5></fC07><fN21><s1>306</s1></fN21></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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